In the paper we report a soft, reliable, and scalable method based on compressed CO2 for obtaining nanoconjugates of recombinant human epidermal growth factors and nanovesicles. These nanoconjugates exhibit appropriate physicochemical properties together with an antimicrobial activity preventing infections that promote complete closure of complex wounds. Therefore, such nanoconjugates are a potential nanomedicine for the topical treatment of complex wounds, particularly diabetic foot ulcers.
The article has been authored by researchers from Nanomol Technologies SL, Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Center for Genetic Engineering and Biotechnology (CIGB), Aarhus University and Leitat Technological Center. https://doi.org/10.1002/adtp.202000260