Particle size is the most important physical property of particulate samples. Particle size has a direct influence on material properties such as reactivity or dissolution rate, stability in suspension, efficacy of delivery in drug delivery systems, texture and feel of food ingredients, appearance in powder coatings and inks, etc.
Measuring particle size and understanding how it affects your products and processes can be critical to the success of many manufacturing businesses.
We are experts on the use of world’s most widely used particle size analyzers, Malvern Mastersizer Laser Diffraction instrument. We are equipped by the latest generation version of this instrument, Mastersizer 3000, a particle size analyzer that delivers accurate particle size distributions for both wet and dry dispersions, over the nanometer to millimeter particle size ranges.
We offer the following services related to particle size studies by laser diffraction on powdered and suspended samples:
- Determination of particle size distribution (PSD) from wet and dry dispersion route.
- Development and validation of methods for determination of PSD according to guidelines of the ISO13320 standard and/or USP <429>
As well as particle size, the shape of constituent particles can also have a significant impact upon the performance or processing of particulate materials. Particle shape measurements in addition to particle size are extremely useful in order to gain a better understanding of any particle-based product (pharmaceutical actives, drug delivery systems, ceramic filters,food ingredients).
In Nanomol Technologies we are also equipped by Malvern Morphologi G3S, an automated image analysis tool being a high resolution direct technique for characterizing particles from around 1 micron up to several millimeters in size. Individual particle images are captured from dispersed samples and analyzed to determine their particle size, particle shape and other physical properties. Statistically representative distributions of parameters can be constructed by measuring tens to hundreds of thousands of particles per measurement. These size and shape morphological parameters are Circle equivalent (CE) diameter, length, width, perimeter, area, max distance, sphere equivalent (SE) volume, fiber total length, fiber width, Aspect ratio, circularity, convexity, elongation, high sensitivity (HS) circularity, solidity.
We offer our expertise in morphological characterization by image analysis for performing studies on:
- Measurement of shape differences where particle size alone does not give differentiation
- Measurement of statistical distribution of any of the above size and shape particle parameters.
- Detection and/or enumeration of agglomerates, oversized particles or contaminant particles
- Size measurement of non-spherical particles such as needle shaped crystals
- Validation of particle size measurements already performed by other techniques such as laser diffraction.
We are experts and advanced users of characterization tools for analysing:
- Size, zeta potential and concentration of nanoparticles in suspension using Dynamic Light Scattering (DLS) instruments
- Stability of particles and colloids in suspension with Multiple Light Scattering – Identification and rapid quantification of sedimentation phenomena, flocculation and creaming
- Particle morphological parameters by optical and electron microscopy techniques